Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gnrh1  gonadotropin releasing hormone 1   (Synonyms: LHRH, LNRH)
Results	Reference
1	J:222928 Cariboni A, Andre V, Chauvet S, Cassatella D, Davidson K, Caramello A, Fantin A, Bouloux P, Mann F, Ruhrberg C, Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome. J Clin Invest. 2015 Jun;125(6):2413-28
1	J:187711 Cariboni A, Andrews WD, Memi F, Ypsilanti AR, Zelina P, Chedotal A, Parnavelas JG, Slit2 and Robo3 modulate the migration of GnRH-secreting neurons. Development. 2012 Sep;139(18):3326-31
1	J:175836 Cariboni A, Davidson K, Dozio E, Memi F, Schwarz Q, Stossi F, Parnavelas JG, Ruhrberg C, VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development. 2011 Sep;138(17):3723-33
1	J:339840 Causeret F, Fayon M, Moreau MX, Ne E, Oleari R, Parras C, Cariboni A, Pierani A, Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages. J Comp Neurol. 2023 Aug;531(12):1229-1243
1*	J:235891 Cimino I, Casoni F, Liu X, Messina A, Parkash J, Jamin SP, Catteau-Jonard S, Collier F, Baroncini M, Dewailly D, Pigny P, Prescott M, Campbell R, Herbison AE, Prevot V, Giacobini P, Novel role for anti-Mullerian hormone in the regulation of GnRH neuron excitability and hormone secretion. Nat Commun. 2016 Jan 12;7:10055
1	J:127370 Cogliati T, Delgado-Romero P, Norwitz ER, Guduric-Fuchs J, Kaiser UB, Wray S, Kirsch IR, Pubertal Impairment in Nhlh2 Null Mice Is Associated with Hypothalamic and Pituitary Deficiencies. Mol Endocrinol. 2007 Dec;21(12):3013-3027
1	J:168231 Forni PE, Fornaro M, Guenette S, Wray S, A role for FE65 in controlling GnRH-1 neurogenesis. J Neurosci. 2011 Jan 12;31(2):480-91
1	J:81465 Giacobini P, Giampietro C, Fioretto M, Maggi R, Cariboni A, Perroteau I, Fasolo A, Hepatocyte growth factor/scatter factor facilitates migration of GN-11 immortalized LHRH neurons. Endocrinology. 2002 Sep;143(9):3306-15
1	J:96891 Giacobini P, Kopin AS, Beart PM, Mercer LD, Fasolo A, Wray S, Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. J Neurosci. 2004 May 19;24(20):4737-48
1	J:141067 Giacobini P, Messina A, Morello F, Ferraris N, Corso S, Penachioni J, Giordano S, Tamagnone L, Fasolo A, Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complex. J Cell Biol. 2008 Nov 3;183(3):555-66
1*	J:240579 Howard SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr HL, Metherell LA, Sternberg MJ, Cabrera CP, Warren HR, Barnes MR, Quinton R, de Roux N, Young J, Guiochon-Mantel A, Wehkalampi K, Andre V, Gothilf Y, Cariboni A, Dunkel L, IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. EMBO Mol Med. 2016 Jun;8(6):626-42
1	J:191667 Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP, SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
1	J:257035 Kim YJ, Osborn DP, Lee JY, Araki M, Araki K, Mohun T, Kansakoski J, Brandstack N, Kim HT, Miralles F, Kim CH, Brown NA, Kim HG, Martinez-Barbera JP, Ataliotis P, Raivio T, Layman LC, Kim SH, WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2018 Feb;19(2):269-289
1*	J:63183 Kramer PR, Guerrero G, Krishnamurthy R, Mitchell PJ, Wray S, Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha. Mech Dev. 2000 Jun;94(1-2):79-94
1*	J:65758 Kramer PR, Wray S, Midline nasal tissue influences nestin expression in nasal-placode-derived luteinizing hormone-releasing hormone neurons during development. Dev Biol. 2000 Nov 15;227(2):343-57
1	J:207602 Kumar D, Freese M, Drexler D, Hermans-Borgmeyer I, Marquardt A, Boehm U, Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero. J Neurosci. 2014 Mar 5;34(10):3756-66
1	J:226927 Kumar D, Periasamy V, Freese M, Voigt A, Boehm U, In Utero Development of Kisspeptin/GnRH Neural Circuitry in Male Mice. Endocrinology. 2015 Sep;156(9):3084-90
1	J:174086 Layman WS, Hurd EA, Martin DM, Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome. Hum Mol Genet. 2011 Aug 15;20(16):3138-50
1	J:133906 Lee JM, Tiong J, Maddox DM, Condie BG, Wray S, Temporal migration of gonadotrophin-releasing hormone-1 neurones is modified in GAD67 knockout mice. J Neuroendocrinol. 2008 Jan;20(1):93-103
1	J:343285 Lettieri A, Oleari R, van den Munkhof MH, van Battum EY, Verhagen MG, Tacconi C, Spreafico M, Paganoni AJJ, Azzarelli R, Andre' V, Amoruso F, Palazzolo L, Eberini I, Dunkel L, Howard SR, Fantin A, Pasterkamp RJ, Cariboni A, SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability. Nat Commun. 2023 Dec 7;14(1):8097
1	J:120902 Magni P, Dozio E, Ruscica M, Watanobe H, Cariboni A, Zaninetti R, Motta M, Maggi R, Leukemia inhibitory factor induces the chemomigration of immortalized gonadotropin-releasing hormone neurons through the independent activation of the Janus kinase/signal transducer and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling pathways. Mol Endocrinol. 2007 May;21(5):1163-74
1	J:308970 Mancini A, Howard SR, Marelli F, Cabrera CP, Barnes MR, Sternberg MJ, Leprovots M, Hadjidemetriou I, Monti E, David A, Wehkalampi K, Oleari R, Lettieri A, Vezzoli V, Vassart G, Cariboni A, Bonomi M, Garcia MI, Guasti L, Dunkel L, LGR4 deficiency results in delayed puberty through impaired Wnt/beta-catenin signaling. JCI Insight. 2020 Jun 4;5(11)
1	J:242704 Marcos S, Monnier C, Rovira X, Fouveaut C, Pitteloud N, Ango F, Dode C, Hardelin JP, Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice. Hum Mol Genet. 2017 Jun 01;26(11):2006-2017
1	J:204198 Memi F, Abe P, Cariboni A, MacKay F, Parnavelas JG, Stumm R, CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability. J Neurosci. 2013 Oct 30;33(44):17527-37
1	J:177773 Messina A, Ferraris N, Wray S, Cagnoni G, Donohue DE, Casoni F, Kramer PR, Derijck AA, Adolfs Y, Fasolo A, Pasterkamp RJ, Giacobini P, Dysregulation of Semaphorin7A/beta1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility. Hum Mol Genet. 2011 Dec 15;20(24):4759-74
1*	J:203635 Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N, Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 2;92(5):725-43
1*	J:20745 Naruse I, Fukui Y, Keino H, Taniguchi M, The arrest of luteinizing hormone-releasing hormone neuronal migration in the genetic arhinencephalic mouse embryo (Pdn/Pdn). Brain Res Dev Brain Res. 1994 Sep 16;81(2):178-84
1	J:340419 Paganoni AJJ, Cannarella R, Oleari R, Amoruso F, Antal R, Ruzza M, Olivieri C, Condorelli RA, La Vignera S, Tolaj F, Cariboni A, Calogero AE, Magni P, Insulin-like Growth Factor 1, Growth Hormone, and Anti-Mullerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development. Int J Mol Sci. 2023 Aug 22;24(17)
1	J:313294 Raucci F, Tiong JD, Wray S, P75 nerve growth factor receptors modulate development of GnRH neurons and olfactory ensheating cells. Front Neurosci. 2013;7:262
1	J:276971 Saadi H, Shan Y, Marazziti D, Wray S, GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice. Front Cell Neurosci. 2019;13:200
1	J:299740 Schmid T, Boehm U, Braun T, GnRH neurogenesis depends on embryonic pheromone receptor expression. Mol Cell Endocrinol. 2020 Dec 1;518:111030
1	J:109381 Schwarting GA, Kostek C, Bless EP, Ahmad N, Tobet SA, Deleted in colorectal cancer (DCC) regulates the migration of luteinizing hormone-releasing hormone neurons to the basal forebrain. J Neurosci. 2001 Feb 1;21(3):911-9
1*	J:300754 Shan Y, Farmer SM, Wray S, Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2009493118
1	J:309185 Shan Y, Saadi H, Wray S, Heterogeneous Origin of Gonadotropin Releasing Hormone-1 Neurons in Mouse Embryos Detected by Islet-1/2 Expression. Front Cell Dev Biol. 2020;8:35
1	J:103333 Temple JL, Wray S, Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system. J Neuroendocrinol. 2005 Sep;17(9):591-9
1*	J:207824 Tiong JD, Pakiam JG, Wray S, Gonadotropin releasing hormone-1 expression in incisors of mice. Endocrinology. 2004 Aug;145(8):3608-12
1	J:101090 Toba Y, Pakiam JG, Wray S, Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse. Eur J Neurosci. 2005 Jul;22(1):79-92
1*	J:294882 Vanacker C, Trova S, Shruti S, Casoni F, Messina A, Croizier S, Malone S, Ternier G, Hanchate NK, Rasika S, Bouret SG, Ciofi P, Giacobini P, Prevot V, Neuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction. EMBO J. 2020 Aug 5;:e104633
1	J:242190 Vastagh C, Schwirtlich M, Kwakowsky A, Erdelyi F, Margolis FL, Yanagawa Y, Katarova Z, Szabo G, The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons. Dev Neurobiol. 2015 Mar;75(3):249-70
1*	J:304806 Wray S, Grant P, Gainer H, Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode. Proc Natl Acad Sci U S A. 1989 Oct;86(20):8132-6
1*	J:21489 Wray S, Key S, Qualls R, Fueshko SM, A subset of peripherin positive olfactory axons delineates the luteinizing hormone releasing hormone neuronal migratory pathway in developing mouse. Dev Biol. 1994 Nov;166(1):349-54
1*	J:193307 Wray S, Nieburgs A, Elkabes S, Spatiotemporal cell expression of luteinizing hormone-releasing hormone in the prenatal mouse: evidence for an embryonic origin in the olfactory placode. Brain Res Dev Brain Res. 1989 Apr 1;46(2):309-18